Yuki Cross
Yuki was attacked by a crazed vampire at the age of 5, but was saved by Kaname and brought her to Headmaster Cross. She is now 15 years old. Yuki is a strict enforcer of the rules between the day and night classes. She is very responsible and kind. She’s in love with Kaname, because he saved her and visited her as she grew older, but she is currently pretty shy around him. Since Kaname adores her, she is reluctantly accepted by the night class. She cared for Zero the night Headmaster Cross brought him home 4 years ago and has been his close friend ever since. She refuses to let Zero turn into a Level E vampire, and promises him that she’ll personally kill him if that ever happens. She sympathizes with the pain Zero must be going through with craving blood, and since he can’t handle the blood tablets, she persuades him to take her blood whenever he needs it.
Zero Kiryu
Zero’s family was slaughtered by pure blood vampire 4 years before the present story. Headmaster Cross found him and took him in. He knew Zero would eventually become a vampire since he was bitten in the attack, so he had the tattoo put on Zero’s neck as a sort of spell in hopes of preventing the change. Since it didn’t work, the tattoo now acts as a safety measure for when he gets out of control; all someone has to do is touch the tattoo with a metal charm that has Zero’s blood on it, which is on a bracelet Yuki wears. Zero comes from a long line of famous vampire hunters. He was trained in his hunting skills by Yagari Toga. Zero has a seething hatred towards vampires and therefore is constantly struggling with himself. He doesn’t like Kaname coming near Yuki, and is pretty protective of her. He hates himself for attacking Yuki and continually drinking from her. He dreams of the day he can take his revenge on the woman who killed his family.
Kuran Kaname
Kaname is the president of Night Class and a seemingly gentle person. He is one of few pure blood vampires in existence and is therefore highly respected by the night class. He had fallen for Yuki ever since he saved her as a child and always watches over her. He wants to be closer to her, but senses how shy she is about it. Kaname knew of Zero eventually becoming a vampire and despises him for feeding from Yuki. Kaname has asked Headmaster Cross to put Zero in the night class, but to no avail. Kaname would do away with Zero if it wouldn’t hurt Yuki so badly. When Shizuka comes to Cross Academy, Kaname commits the greatest sin among vampires by killing her, a pure blood. Kaname is told by Kain that he saw Zero near her crumbles body, and he decides to report to the Council of Ancients that Zero killed Shizuka.
Yori
Yuki's friend and roommate. Seems to be a calm girl and a good friend to Yuki.
Aido Hanabusa
Aido is a flirt and often jokes about feeding from girls. He once fed from a small wound on Yuki's hand, which infuriated Kaname. Aido hangs around with his cousin and friend, Kain. Aido has demonstrated that he has the power to turn water into ice, or to just create ice out of thin air. The adoring girls of the Day Class call him "Idol". Aido witnesses Kaname killing Shizuka, but doesn't tell anyone of what he saw.
Kain Akatsuki
Kain is Aido’s cousin and roommate. He’s usually hanging around with idol and lets him do as he pleases. The fan girls in the Day Class nicknamed him "Wild", because of he looks wild. When Shizuka died, Kain, saw Zero holding his gun in the room where she was killed, and reports to Kaname what he saw.
Souen Ruka
Ruka is a friend of Kaname’s. She doesn’t seem to think too highly of humans or why vampires would want to socialize with them. She is very possessive of Kaname because she is in love with him. He once drank her blood, which is said to create strong feelings for the one whose blood is being taken. Ruka believes that to be true, since she now cares so much for Kaname. She tries to offer Kaname her blood again, but he politely declines, which hurts her feelings.
Ichijo Takuma
Ichijo is vice-president of the Night Class, he is a noble-class vampire nearly as powerful as Kaname, whom he is close to and respects. Takuma appears very un-vampire like with his cheerful and enthusiastic demeanor, he lacks the dark atmosphere that surrounds most vampires, making him appear more like a human. His favorite reading material is manga. Ichijo maintains a close friendship with Senri Shiki, whose great grandfather is also a member of the council. He is also good friends with Rima Touya.
Shiki Senri
Shiki is One of the youngest Night Class members. He works as a model with Rima Touya. When the Night Class is given orders to hunt down a level E vampire, Shiki is usually the one we see out hunting the level E vampires. He has a whip-like weapon which develops from his blood. His father is Rido Kuran, making him Kaname's cousin, and his mother's uncle is part of the council. His mother was also a former actress, making the Shiki family well known. Shiki's body is currently possessed by his father's soul, who is supposed to be dead.
Seiren
is a student of the Night Class, she is Kaname's unofficial bodyguard. She is usually the first to defend Kaname from anyone she regards as a threat. She barely refrains from killing Zero when he threatens Kaname with the Bloody Rose.
Rima Tooya
Rima works as a model alongside Senri Shiki. Her exact relationship with Shiki is unknown, though they are almost always seen together. She cares deeply for Shiki and possesses a personality similar to his. Rima possesses either lightning or electricity powers
Maria Kurenai
Maria is a frail girl and a distant relative of Shizuka. When first introduced to the story, Maria's body is being used by the spirit of Shizuka (with the permission of Maria). She causes trouble for being so forward with the other night class students and by running around campus during the day. She has an interest in Yuki and tells her on more than one occasion that she wants her blood. Once Shizuka is done using Maria's body, she returns to her normal self and goes home with her parents.
Shizuka Hiou
Shizuka is the pure blood vampire that killed Zero parents and took his twin brother Ichiru away. It is rumored among other vampires that she went mad and disappeared after attacking the Kiryuu family. She held a grudge against the Kiryuu family after they followed orders to kill her former human vampire lover. She took Ichiru as a servant and cared for him, and turned Zero into a vampire. By killing the Kiryuu's, she became wanted by the Council of Ancients for viciously slaughtering humans. She returns to Cross Academy by possessing the body of a girl name Maria Kurenai. She tells Yuki she can save Zero, but Yuki would either have to kill Kaname or give her like over to her. Shizuka returns to her real body in order to gain strength from taking Yuki's blood, but Zero stops her. She then drinks from Zero, but when she leaves him, she is caught by Kaname and killed by him.
Ichiru Kiryuu
Zero's younger twin brother. When they were younger, they were both taught by Toga Yagari to become vampire hunters. Ichiru, however did not seem to share Zero's natural ability and was often ill. Zero and Ichiru were very close as children, although later Ichiru claims to have hated Zero after overhearing that his parents preferred Zero over himself.
Shizuka let Ichiru drink her blood to strengthen him and cure his chronic ill health, although she did not turn him into a vampire and he remains a human. He now attends Cross Academy as a Day Class student by the orders of Shiki's father, Rido Kuran (and by Zero's permission). It appears Rido has promised Ichiru that he will kill those who killed Shizuka Hio, which is probably the main reason why Ichiru is working for Rido Kuran.
Shizuka let Ichiru drink her blood to strengthen him and cure his chronic ill health, although she did not turn him into a vampire and he remains a human. He now attends Cross Academy as a Day Class student by the orders of Shiki's father, Rido Kuran (and by Zero's permission). It appears Rido has promised Ichiru that he will kill those who killed Shizuka Hio, which is probably the main reason why Ichiru is working for Rido Kuran.
Headmaster Cross
Yuki's adoptive father, who also took Zero into his home for several years. Headmaster Cross dreams of peace between humans and vampires, and established the Night Class to promote understanding between the two races. Cross is shown to have a habit of provoking Zero and is eccentric in some ways, but he has a serious side as well. It is revealed in Chapter 27 that he is a former vampire hunter. He also seems to be close to Kaname, and knows Kaname's parents (both of whom are dead and founded the Cross Academy peace treaty), since he is indebted to them. He has always known that Yuki was a pureblood vampire, but chose not to reveal it.
Yagari Toga
Yagari was Zero’s teacher in vampire hunting as a child. He is currently the top vampire hunter, since the Kiryu family is no longer around. He lost an eye to a vampire attack because Zero pleaded for him to have mercy on the turned human he was going to kill. Yagari was sent to Cross Academy by someone to see if Zero was under control, and to eliminate him if he wasn’t. During his time at Cross Academy, he teaches a Night Class. He had originally brought Zero to Headmaster Cross and wanted him to care for Zero after his attack.